The Tokai Journal of Experimental and Clinical Medicine, also referred to as Tokai Journal, is an official quarterly publication of the Tokai Medical Association. Tokai Journal publishes original articles that deal with issues of clinical, experimental importance to medical science and related fields. Manuscripts may be submitted as full-length Original Articles or Brief Communications. Review articles in principle are considered for publication by invitation only. Tokai Journal also publishes case reports and case series reports.

Articles accepted for publication in Tokai Journal cannot be reproduced elsewhere without written permission from the Tokai Medical Association. In addition, Tokai Journal will not be held responsible for the opinions of the authors expressed in the published articles.

Instruction for Authors

Requirement for authors
The first and the corresponding authors need to be members of the Tokai Medical Association. To newly join the Tokai Medical Association, please contact to the Office of Tokai Medical Association. The annual membership fee is ¥3,000.

Preparation of manuscripts (Original Articles and Brief Communications)
Manuscripts should be organized as follows: Title page (the first page), Abstract (the second page), and the main body of the manuscript consisting of “Introduction,” “Materials and Methods,” “Results,” “Discussion,” “Acknowledgements,” “References,” “Tables,” and “Figure Legends.” Font size should be 12-point throughout the manuscript. For preparing the text, the current or previous version of Microsoft Word is recommended. Otherwise, the text may be submitted in the text file format. A covering letter should also accompany the manuscript. Figures should be prepared as a separate file. Authors for whom English is not his or her first language are required to submit their manuscript with an accompanying letter certifying that the manuscript has been edited by an English-speaking editor.

Authors are encouraged to use generic names for drugs and chemicals.

(1) Title page
As the first page of the manuscript submission file, The title page should provide (a) title of the manuscript (120 characters maximum), (b) full name of all authors, (c) full addresses of the departments and institutions where the work was performed, (d) a running head (80 characters maximum including spaces), and (e) name, address, telephone and fax numbers, and e-mail address of the corresponding author, who serves as contact.

(2) Abstract
Repeat names of the authors and the title of the manuscript at the top of the page. The body of the abstract should not exceed 200 words, and should be structured into the sub-sections “Objective,” “Methods,” “Results,” and “Conclusion(s).” Following the abstract, a maximum of five (5) keywords should be selected and indicated. For submission, the abstract should be submitted as its own file.

(3) Text
The main body of the manuscript should consist of “Introduction,” “Materials and Methods” or “Patients and Methods,” “Results,” “Discussion,” “Acknowledgments,” “References,” “Tables,” and “Figure Legends.”

1. Introduction
This section should position the study with regard to objective, rationale, and preceding works of other authors.

2. Materials and Methods
This section should contain a statement that “The investigation conforms with The Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health (NIH Publication No. 85-23, revised 1996)” for studies involving experimental animals, or that “The investigation conforms with the principles outlined in the Declaration of Helsinki” (Cardiovascular Research 1997; 35: 2-4) when human subjects were used. The methods section should be sufficiently detailed for repetition of the study by other scientists.

3. Results
If pertinent, the section may be divided into headed sub-sections. For presentation of data, figures are preferred to tables. Also, extensive numerical data should appear in Figure Legends rather than in the main body of the text. SI units should be used.

4. Discussion
This section should not contain paragraphs dealing with topics that are beyond the scope of the study.

5. Acknowledgments

6. References
References should be numbered in the order of appearance, with reference numbers given in the text in parentheses. If the bibliography contains more than six authors, “et al.” should be added following the sixth author. Abbreviations for journal titles should follow The Journal Indexes in Index Medicus. Bibliography style is as follows:

Regular papers
Suzuki Y, Tokuda Y, Saito Y, Umemura S, Osamura RY. Clinicopathological correlation between expression of PTHrP receptor and various prognostic factors in breast cancer without axillary lymph node metastasis. Tokai J Exp Clin Med 2005; 30: 127-32.

Wit AL, Janse MJ. The Ventricular Arrythmias of Ischemia and Infarction. Electrophysiological Mechanisms. Mount Kisco, NY: Futura Publishing Company, Inc, 1992.

Chapter in book
Weber KT. Cardiac Interstitium: Extracellular Space of the Myocardium. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, eds. The Heart and Cardiovascular System. Scientific Foundations, 2nd ed. New York: Raven Press, 1991: 1465-1480.

7. Figure Legends

8. Figures/Tables
These should be attached as separate files (entitled “Figure 1” or “Table 2” for example). Figures should be of high resolution (300 dpi or greater) and in one of the following formats: TIFF, BMP, JPG, PDF, or EPS. Any lettering and mark in the figures should be large enough to withstand photographic reduction. Note that due to the capacity of electronic transfer, the size of figure files is limited to 10 MB per manuscript. For figure files exceeding 10 MB, submit the files on CD-R.

Manuscripts should be submitted electronically by the corresponding author at The submission is required to be uploaded as three files: 1) the abstract, 2) the manuscript (with title page; not as a PDF file), and 3) a covering letter including the following declarations: i) that “the manuscript, or part of it, neither has been published (except in form of abstract or thesis) nor is currently under consideration for publication by any other journal,” and, ii) that the co-author(s) has read the manuscript and approved its submission to Tokai Journal. The covering letter should also indicate the classification of the manuscript as either“ Original Article,” “Brief Communication,” or other. E-mail address of all co-author(s) should be informed.

Statement of Conflict
Tokai Journal requires all authors of submitted manuscripts to disclose in the covering letter significant financial arrangements with commercial companies that produce, distribute, or sell products that are the subjects of studies reported in the manuscript or with competitors of such companies. Any research support must also be acknowledged in the Acknowledgments section.

Submission of a manuscript implies that the authors agree to transfer its copyright to the Tokai Medical Association. Upon submission, a copyright transfer form, which can be found following these guidelines, should be signed by all authors and faxed to the Offfice of the Tokai Medical Association (see below for the fax number). The form may be photocopied to distribute to co-authors for signature.

Office of the Tokai Medical Association
3rd Bldg. Library Office
143 Shimokasuya, Isehara 259-1193
Tel: 0463-93-1121 (81-463-1121 from outside Japan) ex. 4860
Fax: 0463-90-2007 (81-463-90-2007 from outside Japan)